What's Ramona up to? Big sister Beezus Quimby tries to be patient with her four-year-old little sister, Ramona, but it isn't easy, not when Ramona powders her nose with marshmallows and invites her nursery school class to a party without telling her family. Sometimes Beezus doesn't like Ramona, but the girls are sisters and that means they will always love each other—just not every single minute.